David Sinclair
Hosted by David Sinclair
A Harvard geneticist breaks down the science of aging, offering research-backed insights and practical advice for extending healthspan.
This is a solo-hosted, educational deep-dive into the science of longevity. Dr. Sinclair acts as a professor, translating his own lab's research and the broader field's findings into dense, lecture-style episodes. The show focuses heavily on the 'why' behind aging—proposing it's a treatable disease caused by a loss of epigenetic information—before outlining potential solutions.
“Unlike many health podcasts, the host is a leading researcher actively making discoveries in the field he discusses, most notably his Information Theory of Aging. The show's unique value is this direct line from the lab to the listener, explaining breakthrough concepts like epigenetic reprogramming before they are widely known.”
Who hosts this show
Dr. David A. Sinclair is a tenured Professor of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for Biology of Aging Research. His research focuses on the molecular biology of aging, particularly sirtuins, NAD+ metabolism, and his "Information Theory of Aging." He is the author of the New York Times bestseller "Lifespan: Why We Age—And Why We Don't Have To" and hosts this podcast to translate complex science into actionable health insights.
Credentials & credits
- Professor of Genetics, Harvard Medical School
- Co-Director, Paul F. Glenn Center for Biology of Aging Research at Harvard
- Ph.D. in Molecular Genetics, University of New South Wales
- Officer of the Order of Australia (A.O.)
- Author, "Lifespan: Why We Age—And Why We Don't Have To"
- Co-Chief Editor, Aging (scientific journal)
Other ventures
- Tally Health (Co-founder)
- Life Biosciences (Co-founder)
- MetroBiotech (Co-founder)
- EdenRoc Sciences (Co-founder)
- Lifespan.com (Community Platform)
- Sirtris Pharmaceuticals (Co-founder)
What kind of podcast
- Country
- United States
- Region
- usa
When new episodes drop
- 01
- 02The World Record for Human LifespanJun 13, 2026 · 3 min
- 03
- 04
- 05What To Do For Longevity | Lifespan with Dr. David Sinclair Rewind EpisodeMay 5, 2026 · 59 min
- 06
Notable episodes
- 01The Longevity Revolution Is Here | Lifespan with Dr. David Sinclair - Season 2, Episode 1
This episode introduces the core thesis of the show: the Information Theory of Aging. It also announces the major news that an epigenetic reprogramming therapy developed from the lab's research is entering human clinical trials for blindness.
- 02Fasting as a Path to Longevity: The Facts | Lifespan with Dr. David Sinclair - Season 2, Episode 2
A comprehensive, evidence-based breakdown of calorie restriction and fasting. It covers the history, the science (mTOR, AMPK, Sirtuins), and provides a practical roadmap for implementation, showcasing the show's blend of deep science and actionable advice.
- 03Biotracking, Age Reversal & Other Advanced Health Technologies | Lifespan with Dr. David Sinclair #8
This episode from Season 1, co-hosted with Matthew LaPlante, focuses on the practical application of technology for health monitoring. It covers wearable sensors and biological age tests, which are central themes for the show's tech-savvy audience.
What you'll be asked on this show
The podcast is presented as a solo lecture, with Dr. Sinclair speaking directly to the camera from a desk. [U0z4NvbZHm4] It makes heavy use of on-screen graphics, scientific charts, and historical images to illustrate complex topics. [U0z4NvbZHm4] While primarily a monologue, some earlier episodes feature journalist Matthew LaPlante as a co-host to guide the discussion.
Questions David Sinclair keeps coming back to
- “Why do some people preserve function so far beyond the norm?”
- “What does the science say?”
- “How can we each individually know and learn what's good for us?”
- “What if at 80 you had another 40 years of healthy life ahead?”
- “Can we get similar longevity benefits without having to live on a calorie restricted diet?”
- “Will you lose your muscle if you fast?”
- “What happens to your hormones, your sex drive, and your mood when you're fasting?”
Signature segments
- · The 'Lifespan Smartboard' for visualizing data
- · Use of on-screen graphics and scientific paper citations
- · Host presenting from a desk with a laptop and mug
- · Explanation of the 'Ls 122' logo (referencing Jeanne Calment)
- · Sharing personal anecdotes and routines
Topics covered repeatedly
Who gets booked here
The show does not feature traditional interview guests. Instead, Dr. Sinclair references the work and findings of numerous scientists, Nobel laureates, and historical figures to build his case, often showing their pictures and citing their studies. [U0z4NvbZHm4, YRGejckRNpQ]
Where to find this show
Audience & reach
Sponsors include makers of health tracking wearables (Whoop, Withings) and metabolic supplements (Ketone-IQ). This suggests a target audience of affluent, data-driven consumers actively engaged in self-monitoring and bio-optimization, willing to invest in technologies that align with the podcast's scientific principles.
Subscriber and view counts are pulled live from YouTube and re-verified on a 30-day cycle. Listener estimates for the RSS feed aren't published here unless they're host-verified.
Pitch David Sinclair
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People also ask
- What is Dr. Sinclair's real name?
- His full name is David Andrew Sinclair. He is often cited as David A. Sinclair, Ph.D., A.O.
- What are Dr. Sinclair's credentials?
- He is a tenured Professor of Genetics at Harvard Medical School, co-Director of the Paul F. Glenn Center for Biology of Aging Research, and holds a Ph.D. in Molecular Genetics.
- Is the podcast still running?
- Yes, the podcast is active. Season 2 began in June 2026 with new episodes released every two weeks.
- What is the format of the show?
- It is a solo-hosted lecture-style show where Dr. Sinclair explains the science of longevity. [U0z4NvbZHm4] Some earlier episodes featured co-host Matthew LaPlante. It does not typically have interview guests.
- What is the 'Information Theory of Aging'?
- It is Dr. Sinclair's central theory, which posits that aging is caused by the loss of epigenetic information in our cells over time, rather than just accumulated DNA damage. He proposes that this information loss is reversible.
- Where can I listen to the podcast?
- The podcast is available on YouTube, Apple Podcasts, and Spotify, with show notes and additional resources on the Lifespan.com website.
Built from the show's public RSS feed, YouTube, the host's own websites, and the cited sources below. Computed and AI-extracted fields are labelled. Facts only — no private info, no fabrication, no transcripts republished.
Sources & how this page was built
This page is AI-assisted, grounded in the public sources cited below, and host-verifiable. We publish facts only; we do not republish transcripts. If anything here is wrong, the host can claim and correct the page above.Model: gemini-2.5-pro · high confidence
- [01]David Sinclair, A.O., Ph.D. - Paul F. Glenn Center for Biology of Aging Researchglenn.hms.harvard.edu
- [02]David A. Sinclair - Official Websitedavidsinclair.com
- [03]About Professor Sinclairlifespanbook.com
- [04]Tally Healthtallyhealth.com
- [05]David A. Sinclair - Wikipediaen.wikipedia.org
- [06]Lifespan Podcast Official Websitelifespanpodcast.com
- [07]Lifespan: Why We Age – and Why We Don't Have To - Wikipediaen.wikipedia.org
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