Decoding Longevity
Hosted by Decoding Longevity
Two scientists interview leading researchers and founders about the technical and commercial frontiers of longevity science.
This is a technical podcast for an insider audience, focusing on the science and business of aging. The hosts, both active researchers, engage guests—often biotech CEOs and principal investigators—on the specifics of their work, from drug modalities like siRNA to the design of clinical trials. It's less about consumer health tips and more about the fundamental biology and investment landscape of the longevity field.
“Unlike broader health podcasts, Decoding Longevity is distinguished by its sharp focus on the startup ecosystem within geroscience. The co-host dynamic, with two PhDs asking technically specific questions, provides a peer-level conversation with founders about their core science, funding, and clinical pipelines.”
Who hosts this show
Decoding Longevity is co-hosted by Dr. Raghav Sehgal of Yale University and Dr. Macsue Jacques, a Postdoctoral Fellow at Australia's Regenerative Medicine Institute (ARMI). Together, they interview top scientists, founders, and bioethicists to explore the latest research in geroscience, from molecular mechanisms to biotech startups. The show aims to bridge the gap between complex longevity research and a curious public, combating misinformation with rigorous scientific discussion.
Credentials & credits
- Raghav Sehgal, PhD in Computational Biology from Yale University.
- Macsue Jacques, PhD, Postdoctoral Fellow at the Australian Regenerative Medicine Institute (ARMI).
- Raghav Sehgal, Forbes 30 Under 30 honoree.
- Raghav Sehgal, Director of Bioinformatics at Healthy Longevity Clinic.
- Raghav Sehgal, Scientific Principal at Longevity Tech Fund.
- Macsue Jacques, Researcher in OMICs, exercise, and aging at Monash University.
Other ventures
- Raghav Sehgal: Longevity Tech Fund (Venture Capital).
- Raghav Sehgal: Healthy Longevity Clinic (Personalized Care).
- Raghav Sehgal: SYMPHONYAge (Patented aging biomarker).
- Raghav Sehgal: TEDx Yale Speaker.
What kind of podcast
When new episodes drop
- 01
- 02Metabolism, Immunity & the Biology of Aging: A Conversation with Dr. Eric VerdinMay 27, 2026 · 50 min
- 03
- 04
- 05
- 06Translating Geroscience into Function — A Conversation with Steve KritchevskyApr 1, 2026 · 45 min
- 07How Policy Will Shape the Future of Longevity — A Conversation with Dylan LivingstonMar 26, 2026 · 31 min
- 08Turning Biology of Aging into Medicines: A Conversation with James Peyer, Ph.D.Mar 5, 2026 · 39 min
Notable episodes
- 01What Can Hibernating Squirrels Teach Us About Aging Disease and Human Health? with Dr Ashley Zehnder
A clear example of the show's thesis: interviewing a founder (Fauna Bio) about a novel drug discovery platform based on non-traditional animal models (hibernators).
- 02Metabolism, Immunity & the Biology of Aging: A Conversation with Dr. Eric Verdin
Features the head of the prestigious Buck Institute, showcasing the show's access to top-tier academic leaders in the aging field.
- 03Resetting Cells Without Rewinding Identity: A Conversation with Janine Sengstack, Ph.D.
A deep dive into a specific, cutting-edge therapeutic concept ('cell reset') and the technology (siRNA) being used to achieve it, typical of the show's technical focus.
What you'll be asked on this show
The interview is a structured, two-on-one conversation led by co-hosts Dr. Sehgal and Dr. Jacques. They consistently open by asking about the guest's personal and scientific origin story, often with a question like, "Can you tell us about your PhD journey and the core idea that became your company?" This grounds the science in a personal narrative before they transition to the technical core of the work, asking for clear definitions (e.g., "What are 'cell reset therapeutics' and how are they different?"). The hosts probe for specifics on methodology ("Why use siRNAs...?") and pipeline progress ("Can you walk us through your pipeline...?"). The conversation concludes by zooming out to the guest's long-term vision and a signature closing question asking for a future guest recommendation.
The show is co-hosted by a male and female scientist duo who alternate asking questions. Episodes are tightly structured, typically opening with the guest's origin story before moving to a detailed explanation of their core technology, its applications, and their vision for the future. The hosts provide detailed, scripted introductions to frame the conversation for the listener.
Questions Decoding Longevity keeps coming back to
12 cataloguedIf you're going on this show as a guest, expect some version of each of these. Each note explains when Decoding Longevity reaches for it.
origin
2- Q.01
“What was the core idea or PhD journey that led to your company?”
This is a consistent opening question to establish the guest's origin story and the scientific foundation of their work.
- Q.02
“What led you to focus your career on aging biology?”
Used early in the conversation to understand the guest's personal and professional motivations for entering the geroscience field.
process
4- Q.01
“How would you define [guest's core concept] and how is it different from other approaches?”
The hosts ask this to get a clear, foundational definition of the guest's specific technology, distinguishing it from related concepts.
- Q.02
“Can you explain the core biological mechanism behind your approach?”
This question pushes past the high-level concept to explore the specific biological pathways or actions the therapy targets.
- Q.03
“Can you walk us through your company's current pipeline and its stage?”
A standard mid-interview question to get a concrete update on the company's progress from pre-clinical to clinical trials.
- Q.04
“How does your platform use AI and data to discover or validate targets?”
Asked when a guest's company has a significant computational or machine learning component.
technique
1- Q.01
“Why did you choose [specific technology/modality] for this approach?”
This probes the strategic and scientific rationale for the company's choice of drug delivery or therapeutic platform.
craft
1- Q.01
“What's a surprising example or finding from your research?”
This question is used to elicit compelling, memorable stories or data points that illustrate the power of the guest's thesis.
future
3- Q.01
“What does ultimate success look like for this technology?”
A forward-looking question to understand the grand vision, whether it's treating a specific disease or fundamentally altering aging.
- Q.02
“What are the current limitations or boundaries of this therapeutic approach?”
Asked near the end to explore the potential challenges, risks, or long-term constraints of the technology.
- Q.03
“What are you most excited about for the next five years in this field?”
A common closing question that captures the guest's forward-looking perspective on the broader industry.
advice
1- Q.01
“Who do you think we should invite next to the podcast and why?”
This is the show's signature closing question, used to crowdsource future high-quality guests from their expert network.
Signature segments
- · Signature Closing Question: "Who do you think we should invite next to our podcast and why?"
Topics covered repeatedly
Who gets booked here
Guests are typically PhDs who are founders, CEOs, or C-level scientists at biotech startups in the longevity space (e.g., Fauna Bio, Juvanescence). The show also books established academic leaders from major research institutions like the Buck Institute.
- Dr. Ashley Zehnderon What Can Hibernating Squirrels Teach Us About Aging Disease and Human Health? with Dr Ashley Zehnder
- Dr. Eric Verdinon Metabolism, Immunity & the Biology of Aging: A Conversation with Dr. Eric Verdin
- Dr. Janine Sengstackon Resetting Cells Without Rewinding Identity: A Conversation with Janine Sengstack, Ph.D.
- Dr. Raiany Romanni-Kleinon Redesigning Aging: Ethics, Economics & the Longevity Narrative with Raiany Romanni-Klein, Ph.D.
- Michael Ringel, Ph.D., J.D.on The First Cellular Rejuvenation Therapy in Clinical Trials with Michael Ringel, Ph.D., J.D.
Where to find this show
Audience & reach
The podcast appears to be sponsor-free based on the episodes reviewed. This suggests it is a passion project or supported by the hosts' affiliated institutions. For a sponsor, this offers a clean environment to reach a highly-specialized, high-value audience of researchers and investors in the longevity niche.
Subscriber and view counts are pulled live from YouTube and re-verified on a 30-day cycle. Listener estimates for the RSS feed aren't published here unless they're host-verified.
Pitch Decoding Longevity
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People also ask
- Who are the hosts of Decoding Longevity?
- The podcast is co-hosted by Dr. Raghav Sehgal, a computational biologist from Yale University, and Dr. Macsue Jacques, a postdoctoral research fellow at the Australian Regenerative Medicine Institute.
- Is this podcast still active?
- Yes, the podcast releases new episodes on a weekly or bi-weekly basis.
- What is the format of the show?
- It is an interview-based show where the two co-hosts have a structured conversation with a single guest, typically a scientist, founder, or academic in the longevity field.
- What kind of topics does the podcast cover?
- The show focuses on the science and business of longevity, including geroscience, drug discovery, aging biomarkers, epigenetics, and the biotech startups working in the space.
- How can I suggest a guest for the podcast?
- The hosts have a signature closing question where they ask every guest for a recommendation, suggesting they are actively seeking new experts to interview.
- Where can I listen to Decoding Longevity?
- The podcast is available on major platforms including YouTube, Spotify, and Apple Podcasts.
Built from the show's public RSS feed, YouTube, the host's own websites, and the cited sources below. Computed and AI-extracted fields are labelled. Facts only — no private info, no fabrication, no transcripts republished.
Sources & how this page was built
This page is AI-assisted, grounded in the public sources cited below, and host-verifiable. We publish facts only; we do not republish transcripts. If anything here is wrong, the host can claim and correct the page above.Model: gemini-2.5-pro · high confidence
- [01]ARMI Postdoc Launches Decoding Longevity, A New Anti-Ageing Science Podcastarmi.org.au
- [02]Raghav Sehgal, PhD | Yale School of Medicinemedicine.yale.edu
- [03]Dr. Raghav Sehgal (Personal Website)raghavsehgal.com
- [04]Raghav Sehgal - Foresight Instituteforesight.org
- [05]Macsue Jacques - Google Scholarscholar.google.com
- [06]Decoding Longevity - Listen Noteslistennotes.com
- [07]Decoding Longevity - YouTube Channelyoutube.com
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